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![]() ![]() The model shows that yield, however, is under no direct selection. The relative selective pressure on growth rate and lag time is set by the dilution factor a larger dilution factor favors the adaptation of growth rate over the adaptation of lag time. We find that the fixation probability of a beneficial mutation depends on a linear combination of its growth rate and lag time relative to its immediate ancestor, even under clonal interference. Here we investigate how these traits evolve in laboratory evolution experiments using a minimal model of population dynamics, where the only interaction between cells is competition for a single limiting resource. ![]() In serialdilution evolution experiments, three key traits are the lag time when transitioning from starvation to growth, the exponential growth rate, and the yield (number of cells per unit resource). Selection of mutants in a microbial population depends on multiple cellular traits. ![]()
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